|
KMID : 0861020080230030119
|
|
Korea Journal of Herbology
2008 Volume.23 No. 3 p.119 ~ p.125
|
|
|
Inhibitory Effect of Extract of Teucrium veronicoides on the Production of Inflammatory Cytokines
|
|
Bae Gi-Sang
Park Hee-Je
Kim Do-Yun
Seo Sang-Wan
Park Kyung-Bae
Kim Byung-Jin
Song Je-Moon
Lee Kyung-Yong
Na Cheol
Shin Byung-Cheul
Park Sung-Joo
Song Ho-Joon
Hwang Sung-Yeon
|
|
|
Abstract
|
|
|
Objectives : The purpose of this paper was to investigate the anti-inflammatory effects of extract from Teucrium veronicoides (TV) on the RAW 264.7 cells.
Methods : To evaluate of anti-inflammatory of TV, we examined the cytokine productions on lipopolysacchride (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms using Western blot. Furthermore, We examined LPS-nduced endotoxin shock.
Results : 1. Extract from TV itself does not have any cytotoxic effect. 2. Extract from TV reduced LPS-induced Nitric oxide (NO),interleukin (IL)-1b, IL-6 and IL-10, tumor necrosis factor-a (TNF-a) production in RAW 264.7 cells. 3. TV inhibited the activation of mitogen-activated protein kinases (MAPKs) such as p38, extracelluar signal-regulated kinase (ERK 1/2) and c-Jun NH2-terminal kinase (JNK) and also the degradation of inhibitory kappa B a (Ik-Ba) in the LPS-stimulated RAW 264.7 cells. 3. TV slightly increased the duration of survival after LPS-induced endotoxin shock.
Conclusions : TV down-regulated LPS-induced NO and cytokines production, which could provide a clinical basis for anti-inflammatory properties of TV.
|
|
|
KEYWORD
|
|
|
Teucrium veronicoides, TV, Lipopolysaccharide, LPS, inflammation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|